ODCs

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2 OMIM references -
2 associated genes
10 signs/symptoms

COMMON GENES: 1
PROTEIN INTERACTIONS: 3

2 OMIM references -
4 associated genes
6 signs/symptoms

Hyperostosis corticalis generalisata

Idiopathic juvenile osteoporosis


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	SOST LRP5 LRP5	(0.68) (0.65) (0.52)	LRP5 DKK1 WNT1

Citations in the biomedical literature:

Hyperostosis corticalis generalisata		Idiopathic juvenile osteoporosis
	Synonym(s): - Van Buchem disease		Synonym(s): - IJO - Juvenile osteoporosis

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease

	Classification (ICD10): - Diseases of the musculoskeletal system and connective tissue -		Classification (ICD10): - Diseases of the musculoskeletal system and connective tissue -

	Epidemiological data: Class of prevalence: - Average age onset: - Average age of death: - Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: - Type of inheritance: autosomal dominant

	External references: 2 OMIM references - No MeSH references		External references: 2 OMIM references - No MeSH references

Hyperostosis corticalis generalisata		Idiopathic juvenile osteoporosis
	Very frequent - Autosomal recessive inheritance - Clavicle absent / abnormal - Cortical anomaly / thick bone cortical layer - Dense / thickened skull / calvarium / cranial / facial hyperostosis - Enlarged diaphysis / diaphyses - Enlargment of jaw / large jaw - Osteosclerosis / osteopetrosis / bone condensation - Prognathism / prognathia Frequent - Facial palsy - Sensorineural deafness / hearing loss		Very frequent - Bone pain - Mutiple fractures / bone fragility - Osteoporosis / osteopenia / demineralisation / osteomalacia / rickets Frequent - Abnormal gait - Motor deficit / trouble Occasional - Kyphosis